Interpretation of erythropoietin levels in patients with various degrees of renal anemia
نویسندگان
چکیده
منابع مشابه
Interpretation of erythropoietin levels in patients with various degrees of renal insufficiency and anemia.
BACKGROUND Chronic renal failure leads to hyporegenerative anemia due to erythropoietin deficiency. The creatinine clearance and hemoglobin levels, at which anemia treatment with recombinant erythropoietin should be started, are unclear. Interpretation of serum erythropoietin levels in the context of renal insufficiency remains controversial and was addressed in this study. METHODS Three hund...
متن کاملSingle-dose pharmacokinetics of recombinant human erythropoietin in patients with various degrees of renal failure.
The pharmacokinetic profile of recombinant human erythropoietin (rHuEpo) was studied after a single intravenous dose of 150 U/kg in ten patients with various degrees of renal function: group I, creatinine clearance greater than 80 ml/min, n = 2; group II, creatinine clearance 10-50 ml/min, n = 6; group III, creatinine clearance less than 3 ml/min (patients undergoing haemodialysis) n = 2. Eryth...
متن کاملInterpretation of Erythropoietin and Haemoglobin Levels in Patients with Various Stages of Chronic Kidney Disease
BACKGROUND The production of erythrocytes is regulated by the hormone erythropoietin (EPO), which maintains the blood haemoglobin (Hb) levels constant under normal conditions. Human EPO is a glycoprotein hormone and its synthesis is controlled by the hypoxia-inducible transcription factor. The aim of this study was to establish EPO and Hb levels in patients with chronic kidney disease (CKD), as...
متن کاملErythropoietin Levels in Elderly Patients with Anemia of Unknown Etiology
BACKGROUND In many elderly patients with anemia, a specific cause cannot be identified. This study investigates whether erythropoietin levels are inappropriately low in these cases of "anemia of unknown etiology" and whether this trend persists after accounting for confounders. METHODS This study includes all anemic patients over 60 years old who had erythropoietin measured between 2005 and 2...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2005
ISSN: 0085-2538
DOI: 10.1111/j.1523-1755.2005.247_3.x